1243245-18-2

1243245-18-2 structure

Name: GNF-6231
Chemical Name: GNF-6231
CAS Number: 1243245-18-2
Molecular Formula: C₂₄H₂₅FN₆O₂
Molecular Weight: 448.493
Catalog: Signaling Pathways Stem Cell/Wnt Porcupine
Create Date: 2018-03-13 15:59:04
Modify Date: 2024-01-03 15:02:27
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy.

Name	GNF-6231
Synonyms	N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2-(2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)acetamide [2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl-

Description	GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Porcupine Research Areas >> Cancer
References	[1]. Cheng D et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett. 2016 May 10;7(7):676-80.