GB-83
Modify Date: 2024-01-13 13:40:41
GB-83 structure
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Common Name | GB-83 | ||
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| CAS Number | 1252806-86-2 | Molecular Weight | 548.71600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H44N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GB-83GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons[1]. |
| Name | N-[(2S)-3-Cyclohexyl-1-{[(2S,3S)-1-(2,3-dihydro-1'H-spiro[indene- 1,4'-piperidin]-1'-yl)-3-methyl-1-oxo-2-pentanyl]amino}-1-oxo-2-p ropanyl]-1,2-oxazole-5-carboxamide |
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| Synonym | More Synonyms |
| Description | GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons[1]. |
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| Related Catalog | |
| Target |
PAR2 |
| In Vitro | GB83 (10 µM) blocks the effect of MET-1 (microbial ecosystem therapeutic-1) supernatant on nodose ganglion (NG) neurons[2]. |
| In Vivo | GB83 (5 µg; i.p.) reverses neutrophil elastase‐induced synovitis and pain in PAR2 KO mice[1]. Animal Model: 8-14 weeks, 20-30 g male C57Bl/6 mice (PAR2 KO mice)[1] Dosage: 5 µg Administration: I.p.; 3 times at 10 min before and 110 and 230 min after neutrophil elastase administered Result: Significantly blocked the neutrophil elastase induced increase in vascular perfusion, as well as the number of rolling adherent leukocytes, and also significantly attenuated hindpaw allodynia. |
| References |
| Molecular Formula | C32H44N4O4 |
|---|---|
| Molecular Weight | 548.71600 |
| Exact Mass | 548.33600 |
| PSA | 108.03000 |
| LogP | 5.95000 |
| 5-isoxazoyl-Cha-Ile-spiroindane-1,4'-piperidine |
| Pentanoic acid,5-isothiocyanato |
| 5-Isothiocyanatovaleriansaeure |
| 5-Isothiocyanato-pentanoic acid |
| GB-83 |