TNP-351
Modify Date: 2024-01-16 18:01:10
TNP-351 structure
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Common Name | TNP-351 | ||
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| CAS Number | 125991-51-7 | Molecular Weight | 440.45200 | |
| Density | 1.473g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H24N6O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TNP-351TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1]. |
| Name | (2S)-2-[[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]amino]pentanedioic acid |
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| Synonym | More Synonyms |
| Description | TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1]. |
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| Related Catalog | |
| Target |
Antifolate, DHFR[1] |
| In Vitro | TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1]. The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1]. Cell Viability Assay[1] Cell Line: L1210 and CCRF-CEM cells Concentration: 0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells Incubation Time: 48 hours for L1210 cells; 72 hours for CCRF-CEM cells Result: The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively. |
| References |
| Density | 1.473g/cm3 |
|---|---|
| Molecular Formula | C21H24N6O5 |
| Molecular Weight | 440.45200 |
| Exact Mass | 440.18100 |
| PSA | 198.04000 |
| LogP | 2.24760 |
| Index of Refraction | 1.712 |
| Tnp 351 |
| N-(4-(3-(2,4-Diamino-1H-pyrrolo(2,3-d)pyrimidin-5-yl)propyl)benzoyl)-L-glutamic acid |