Sulfisoxazole

Modify Date: 2024-01-03 11:41:18

Sulfisoxazole Structure
Sulfisoxazole structure
 Common Name Sulfisoxazole
CAS Number 127-69-5 Molecular Weight 267.304
Density 1.4±0.1 g/cm3 Boiling Point 482.2±55.0 °C at 760 mmHg
Molecular Formula C11H13N3O3S Melting Point 195°C
MSDS Chinese USA Flash Point 245.4±31.5 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Sulfisoxazole


Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2].

 Names

Name sulfisoxazole
Synonym More Synonyms

 Sulfisoxazole Biological Activity

Description Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2].
Related Catalog
References

[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.

[2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 482.2±55.0 °C at 760 mmHg
Melting Point 195°C
Molecular Formula C11H13N3O3S
Molecular Weight 267.304
Flash Point 245.4±31.5 °C
Exact Mass 267.067749
PSA 106.60000
LogP 1.01
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.626
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility <0.1 g/100 mL at 22.5 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WO9100000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-(3,4-dimethyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
127-69-5
BEILSTEIN REFERENCE NO. :
0263871
LAST UPDATED :
199706
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C11-H13-N3-O3-S
MOLECULAR WEIGHT :
267.33
WISWESSER LINE NOTATION :
T5NOJ CMSWR DZ& D1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,275,1980 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,275,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,347,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80541 No. of Facilities: 353 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 4053 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80541 No. of Facilities: 258 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 5506 (estimated) No. of Female Employees: 3068 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS WO9100000
HS Code 2935009090

 Synthetic Route

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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 Synonyms

4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
4-Amino-N-(3,4-dimethylisoxazol-5-yl)-benzenesulfonamide
4-Amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
Gantrizin
Sulfisoxazole
T5NOJ CMSWR DZ& D1 E1
N1-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide
Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-
Sulfafurazole
EINECS 204-858-9
MFCD00003150
4-Amino-N-(3,4-d
5-(p-Aminobenzenesulfonamido)-3,4-dimethylisooxazole
4-Amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
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