1-HYDROXYANTHRAQUINONE

Modify Date: 2024-01-02 13:11:37

1-HYDROXYANTHRAQUINONE Structure
1-HYDROXYANTHRAQUINONE structure
 Common Name 1-HYDROXYANTHRAQUINONE
CAS Number 129-43-1 Molecular Weight 224.212
Density 1.4±0.1 g/cm3 Boiling Point 414.8±14.0 °C at 760 mmHg
Molecular Formula C14H8O3 Melting Point 194°C
MSDS N/A Flash Point 218.8±16.6 °C

 Use of 1-HYDROXYANTHRAQUINONE


1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].

 Names

Name 1-hydroxyanthraquinone
Synonym More Synonyms

 1-HYDROXYANTHRAQUINONE Biological Activity

Description 1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].
Related Catalog
In Vivo 1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. Animal Model: Thirty rats[1]. Dosage: 1% HA in diet. Administration: Diet. Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becomingmoribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of totalintake of HA/rat was 76.8 g).
References

[1]. H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 414.8±14.0 °C at 760 mmHg
Melting Point 194°C
Molecular Formula C14H8O3
Molecular Weight 224.212
Flash Point 218.8±16.6 °C
Exact Mass 224.047348
PSA 54.37000
LogP 3.97
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.695

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB7178000
CHEMICAL NAME :
Anthraquinone, 1-hydroxy-
CAS REGISTRY NUMBER :
129-43-1
BEILSTEIN REFERENCE NO. :
1912751
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H8-O3
MOLECULAR WEIGHT :
224.22
WISWESSER LINE NOTATION :
L C666 BV IVJ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
288 gm/kg/68W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
147 gm/kg/42W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
50 umol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,457,1986

 Safety Information

Hazard Codes Xn
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36/37/39
RTECS CB7178000
Packaging Group III
HS Code 2914690090

 Synthetic Route

 Customs

HS Code 2914690090
Summary 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

9,10-Anthracenedione, 1-hydroxy-
EINECS 204-946-7
1-HYDROXYANTHRAQUINONE
1-hydroxyanthracene-9,10-dione
1-Hydroxy-9,10-anthraquinone
HYDROXY-9,10-ANTHRACENEDIONE
MFCD00058946
1-Hydroxy anthraquinone
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