(-)-Catechin gallate(CG)

Modify Date: 2024-01-04 00:17:34

(-)-Catechin gallate(CG) structure	Common Name	(-)-Catechin gallate(CG)
	CAS Number	130405-40-2	Molecular Weight	442.372
	Density	1.8±0.1 g/cm3	Boiling Point	861.7±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₈O₁₀	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	305.0±27.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of (-)-Catechin gallate(CG)

(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

Name	(-)-Catechin Gallate
Synonym	More Synonyms

Description	(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
Related Catalog	Research Areas >> Cancer Natural Products >> Flavonoids
Target	COX-1 COX-2
In Vitro	(-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR50) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts[1].
Cell Assay	Human tongue squamous carcinoma (CAL27) cells and human salivary gland carcinoma (HSG) cells are used. Individual wells of a 96-well microtiter tissue culture plate are inoculated with 0.2 mL of the growth medium containing 2×104 cells/well for a 1-day exposure, 1.5×104 cells/ well for a 2-day exposure and 1×104 cells/well for a 3-day exposure to the test agents. After 1 day of incubation, the growth medium is removed and replaced with exposure medium, with or without varied concentrations of the test agents. In some studies the cells are coexposed to (-)-Catechin gallate (100, 200, 300, 400, and 500 μM) and 100 Units/mL catalase. After 1-3 days of exposure to the test agents, viability is assessed with the neutral red (NR) assay, which is based on the uptake and accumulation of the supravital dye, neutral red (NR)[1].
References	[1]. Babich H, et al. In vitro cytotoxicity of (-)-catechin gallate, a minor polyphenol in green tea. Toxicol Lett. 2007 Jul 10;171(3):171-80.

Density	1.8±0.1 g/cm3
Boiling Point	861.7±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₈O₁₀
Molecular Weight	442.372
Flash Point	305.0±27.8 °C
Exact Mass	442.089996
PSA	177.14000
LogP	2.67
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.825
Storage condition	2~8℃

(-)-Catechin gallate(CG) MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport

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(−)-Catechin gallate

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MFCD00214258

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