(±)-CPSI-1306

Modify Date: 2024-01-13 18:51:43

(±)-CPSI-1306 structure	Common Name	(±)-CPSI-1306
	CAS Number	1309793-47-2	Molecular Weight	310.296
	Density	1.4±0.1 g/cm3	Boiling Point	453.3±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₆F₂N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	227.9±31.5 °C

Use of (±)-CPSI-1306

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

Name	2-[3-(2,4-Difluorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1-(4-morpholinyl)ethanone
Synonym	More Synonyms

Description	(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	MIF[1].
In Vivo	Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease[1]. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2].
Animal Admin	Mice[1] Six- to 8-wk-old female BALB/c mice and ICR mice are used in the study. Age- and sex-matched ICR mice are deprived of food for 20 h and then injected intraperitoneally with STZ (90 mg/kg). Beginning at 6 h after STZ injection, mice are administered CPSI-1306 (1 or 0.1 mg/kg) or PBS daily in a single oral dose for 30 d[1].
References	[1]. Sanchez-Zamora Y, et al. Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. FASEB J. 2010 Jul;24(7):2583-90. [2]. Nagarajan P, et al. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Mol Cancer Res. 2014 Sep;12(9):1292-302.

Density	1.4±0.1 g/cm3
Boiling Point	453.3±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₆F₂N₂O₃
Molecular Weight	310.296
Flash Point	227.9±31.5 °C
Exact Mass	310.112885
LogP	1.27
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.591

2-[3-(2,4-Difluorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1-(4-morpholinyl)ethanone

Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (±)-CPSI-1306
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: CPSI-1306
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: CPSI-1306
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: ￥1320/10 mM * 1 mL in DMSO

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(±)-CPSI-1306

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