1309793-47-2
1309793-47-2 structure
- Name: (±)-CPSI-1306
- Chemical Name: 2-[3-(2,4-Difluorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1-(4-morpholinyl)ethanone
- CAS Number: 1309793-47-2
- Molecular Formula: C15H16F2N2O3
- Molecular Weight: 310.296
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-06-26 20:49:01
- Modify Date: 2024-01-13 18:51:43
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(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
| Name | 2-[3-(2,4-Difluorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1-(4-morpholinyl)ethanone |
|---|---|
| Synonyms |
2-[3-(2,4-Difluorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1-(4-morpholinyl)ethanone
Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)- |
| Description | (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF). |
|---|---|
| Related Catalog | |
| Target |
MIF[1]. |
| In Vivo | Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease[1]. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2]. |
| Animal Admin | Mice[1] Six- to 8-wk-old female BALB/c mice and ICR mice are used in the study. Age- and sex-matched ICR mice are deprived of food for 20 h and then injected intraperitoneally with STZ (90 mg/kg). Beginning at 6 h after STZ injection, mice are administered CPSI-1306 (1 or 0.1 mg/kg) or PBS daily in a single oral dose for 30 d[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 453.3±55.0 °C at 760 mmHg |
| Molecular Formula | C15H16F2N2O3 |
| Molecular Weight | 310.296 |
| Flash Point | 227.9±31.5 °C |
| Exact Mass | 310.112885 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.591 |