PH-002

Modify Date: 2024-01-23 12:50:29

PH-002 structure	Common Name	PH-002
	CAS Number	1311174-68-1	Molecular Weight	491.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₃N₅O₄	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of PH-002

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.

Name	PH-002

Description	PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	116 nM (Apo E4 in FRET)[1].
In Vitro	PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET[1].
In Vivo	PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons)[2].
Cell Assay	Neuro-2a cells stably expressing apoE3 or apoE4 are seeded at 7500-8000 cells/well on PLlysine-coated 24-well plates containing Opti-MEM with either 0.03% DMSO (control) or DMSO plus compound PH-002 (100 nM)[1].
References	[1]. Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26. [2]. Chen HK, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17;287(8):5253-66.

Molecular Formula	C₂₇H₃₃N₅O₄
Molecular Weight	491.58
Storage condition	2-8℃

RIDADR	NONH for all modes of transport

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PH-002
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: PH-002
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: PH-002
Price: $750.0/100mg $1200.0/250mg $2500.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥2750/10 mM * 1 mL in DMSO

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PH-002

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