1311174-68-1
1311174-68-1 structure
- Name: PH-002
- Chemical Name: PH-002
- CAS Number: 1311174-68-1
- Molecular Formula: C27H33N5O4
- Molecular Weight: 491.58
- Catalog: Research Areas Neurological Disease
- Create Date: 2019-01-20 19:44:08
- Modify Date: 2024-01-23 12:50:29
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PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
| Name | PH-002 |
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| Description | PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth. |
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| Related Catalog | |
| Target |
116 nM (Apo E4 in FRET)[1]. |
| In Vitro | PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET[1]. |
| In Vivo | PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons)[2]. |
| Cell Assay | Neuro-2a cells stably expressing apoE3 or apoE4 are seeded at 7500-8000 cells/well on PLlysine-coated 24-well plates containing Opti-MEM with either 0.03% DMSO (control) or DMSO plus compound PH-002 (100 nM)[1]. |
| References |
| Molecular Formula | C27H33N5O4 |
|---|---|
| Molecular Weight | 491.58 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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