NCC-149
Modify Date: 2024-01-11 18:55:51
NCC-149 structure
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Common Name | NCC-149 | ||
|---|---|---|---|---|
| CAS Number | 1316652-41-1 | Molecular Weight | 326.373 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H14N4O2S | Melting Point | 153 °C(dec.) | |
| MSDS | N/A | Flash Point | N/A | |
Use of NCC-149NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1]. |
| Name | N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC8 |
| In Vitro | NCC-149 (5 μM, 3 days) remarkably reduces NeuN expression levels in P19 cells[1]. NCC-149 (0-40 μM, 4 days) reduces embryoid body size in a dose-dependent manner[1]. NCC-149 (5 and 20 μM, 24 h) downregulates P19 cell proliferation[1]. NCC-149 (2.5 and 5 μM, 24 h) leads to cell growth retardation by G2/M phase arrest[1]. Western Blot Analysis[1] Cell Line: P19 cells Concentration: 5 μM Incubation Time: 3 days Result: Remarkably reduced NeuN expression levels. Cell Proliferation Assay[1] Cell Line: P19 cells Concentration: 5 and 20 μM Incubation Time: 24 h Result: Downregulated cell proliferation. Cell Cycle Analysis[1] Cell Line: P19 cells Concentration: 2.5 and 5 μM Incubation Time: 24 h Result: Led to a significant increase in G2/M phase cells, with a slight decrease in S phase cells. RT-PCR[1] Cell Line: P19 cells Concentration: 25 μM or 2.5 and 5 μM Incubation Time: 4 days (25 μM) or 48 h (2.5 and 5 μM) Result: Did not reduce the HDAC8 expression at the mRNA level. Significantly and partially reduced cyclin B1 and cyclin A2 gene expression, respectively. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 153 °C(dec.) |
| Molecular Formula | C16H14N4O2S |
| Molecular Weight | 326.373 |
| Exact Mass | 326.083740 |
| PSA | 108.83000 |
| LogP | 1.60 |
| Index of Refraction | 1.691 |
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N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-
Revision number: 5
yl]benzamide SAFETY DATA SHEET Section1. IDENTIFICATION Product name:N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide
Revision number:5
Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDSNot classified Not classified HEALTH HAZARDS ENVIRONMENTAL HAZARDSNot classified GHS label elements, including precautionary statements Pictograms or hazard symbolsNone Signal wordNo signal word Hazard statementsNone Precautionary statements:None Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance Substance/mixture: Components:N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide >95.0%(LC) Percent: CAS Number:1316652-41-1 NCC-149 Synonyms: Chemical Formula:C16H14N4O2S Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. Skin contact:Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation or rash occurs: Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Get medical advice/attention if you feel unwell. Rinse mouth. Ingestion: Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air- tight goggles. Section5. FIRE-FIGHTING MEASURES Dry chemical, foam, water spray, carbon dioxide. Suitable extinguishing media: Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to from the chemical:generate poisonous fume. N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3- triazol-4-yl]benzamide Section5. FIRE-FIGHTING MEASURES Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Use personal protective equipment. Keep people away from and upwind of spill/leak. Personal precautions, protective equipment and Entry to non-involved personnel should be controlled around the leakage area by emergency procedures: roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Handling is performed in a well ventilated place. Wear suitable protective equipment. Technical measures: Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a refrigerator. Store away from incompatible materials such as oxidizing agents. Heat-sensitive Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust as possible so that workers should not be exposed directly. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator. Follow local and national regulations. Hand protection:Protective gloves. Safety glasses. A face-shield, if the situation requires. Eye protection: Skin and body protection: Protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Solid Crystal- Powder Form: Colour:Pale yellow - Greyish yellow red No data available Odour: pH: No data available Melting point/freezing point:153°C (dec.) Boiling point/range:No data available No data available Flash point: Flammability or explosive limits: Lower:No data available No data available Upper: Relative density:No data available Solubility(ies): [Water]No data available No data available [Other solvents] N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3- triazol-4-yl]benzamide Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Sulfur oxides products: Section11. TOXICOLOGICAL INFORMATION No data available Acute Toxicity: Skin corrosion/irritation: No data available No data available Serious eye damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: No data available IARC = NTP =No data available No data available Reproductive toxicity: Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available Crustacea:No data available Algae:No data available Persistence / degradability: No data available BioaccumulativeNo data available potential(BCF): Mobility in soil Log Pow:No data available Soil adsorption (Koc):No data available Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations UN-No:Not listed Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3- triazol-4-yl]benzamide SECTION 16 - ADDITIONAL INFORMATION N/A |
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