TC-G 1006

Modify Date: 2024-01-11 11:13:58

TC-G 1006 structure	Common Name	TC-G 1006
	CAS Number	1324003-64-6	Molecular Weight	415.36500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₆F₃N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TC-G 1006

S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.IC50 value: 18 nM(EC50) [1]Target: S1P1 agonistWhen dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

Name	4-methoxy-N-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)nicotinamide
Synonym	More Synonyms

Description	S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.IC50 value: 18 nM(EC50) [1]Target: S1P1 agonistWhen dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
References	[1]. Harrington PE, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett. 2011 Nov 23;3(1):74-8.

Molecular Formula	C₂₁H₁₆F₃N₃O₃
Molecular Weight	415.36500
Exact Mass	415.11400
PSA	80.32000
LogP	5.20180
Storage condition	2-8℃

S1P1 Agonist III

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TC-G 1006
Price:
Purity: 98.0%
Stocking Period: Inquiry
Contact: Tom

DC Chemicals Limited
China
Product Name: S1P1 Agonist 8
Price: $Inquiry/25mg $Inquiry/50mg $Inquiry/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S1P1 Agonist III
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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TC-G 1006

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