Compound L

Modify Date: 2024-01-12 08:43:33

Compound L Structure
Compound L structure
Common Name Compound L
CAS Number 1326852-06-5 Molecular Weight 437.42
Density N/A Boiling Point N/A
Molecular Formula C22H20FN5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Compound L


STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].

 Names

Name STL127705

 Compound L Biological Activity

Description STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].
Related Catalog
Target

IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]

References

[1]. Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.

 Chemical & Physical Properties

Molecular Formula C22H20FN5O4
Molecular Weight 437.42
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