MC-Val-Ala-PBD

Modify Date: 2024-01-05 11:05:18

MC-Val-Ala-PBD Structure
MC-Val-Ala-PBD structure
Common Name MC-Val-Ala-PBD
CAS Number 1342820-51-2 Molecular Weight 1089.20000
Density N/A Boiling Point N/A
Molecular Formula C60H64N8O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MC-Val-Ala-PBD


MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].

 Names

Name (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-hexanamido)-3-methylbutanamido)propanoic acid

 MC-Val-Ala-PBD Biological Activity

Description MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].
Related Catalog
Target

Pyrrolobenzodiazepines

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Jeffrey SC, et al. A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Bioconjug Chem. 2013 Jul 17;24(7):1256-63.

 Chemical & Physical Properties

Molecular Formula C60H64N8O12
Molecular Weight 1089.20000
Exact Mass 1088.46000
PSA 236.17000
LogP 7.11240