1342820-51-2

1342820-51-2 structure

Name: MC-Val-Ala-PBD
Chemical Name: (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-hexanamido)-3-methylbutanamido)propanoic acid
CAS Number: 1342820-51-2
Molecular Formula: C₆₀H₆₄N₈O₁₂
Molecular Weight: 1089.20000
Create Date: 2017-11-25 17:19:47
Modify Date: 2024-01-05 11:05:18
MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].

Name	(S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-hexanamido)-3-methylbutanamido)propanoic acid

Description	MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].
Related Catalog	Research Areas >> Cancer
Target	Pyrrolobenzodiazepines
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References	[1]. Jeffrey SC, et al. A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Bioconjug Chem. 2013 Jul 17;24(7):1256-63.