Ro 0437626
Modify Date: 2024-01-06 18:24:55
Ro 0437626 structure
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Common Name | Ro 0437626 | ||
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| CAS Number | 134362-79-1 | Molecular Weight | 525.66300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H35N5O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ro 0437626Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1]. |
| Name | N-[(2R)-1-[[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-1H-benzimidazole-2-carboxamide |
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| Synonym | More Synonyms |
| Description | Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1]. |
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| Related Catalog | |
| Target |
IC50: 3 μM (P2X1 receptor) |
| In Vitro | Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control[2]. |
| In Vivo | Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions[3]. Animal Model: Female rat (urethane-anaesthetized)[3] Dosage: 1 and 10 μmol/kg Administration: I.v. Result: Caused a reduction in postinfusion isovolumetric contractions. |
| References |
| Molecular Formula | C27H35N5O4S |
|---|---|
| Molecular Weight | 525.66300 |
| Exact Mass | 525.24100 |
| PSA | 168.47000 |
| LogP | 3.72930 |
| Cortistatin 14 |