2-Phthalimidehydroxy-acetic acid structure
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Common Name | 2-Phthalimidehydroxy-acetic acid | ||
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CAS Number | 134724-87-1 | Molecular Weight | 221.16600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H7NO5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of 2-Phthalimidehydroxy-acetic acid2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
Name | 2-(1,3-dioxoisoindol-2-yl)oxyacetic acid |
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Synonym | More Synonyms |
Description | 2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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Related Catalog | |
Target |
Alkyl-Chain |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
Molecular Formula | C10H7NO5 |
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Molecular Weight | 221.16600 |
Exact Mass | 221.03200 |
PSA | 83.91000 |
LogP | 0.23670 |
~99% 2-Phthalimidehy... CAS#:134724-87-1 |
Literature: Organic and Biomolecular Chemistry, , vol. 6, # 17 p. 3065 - 3078 |
~70% 2-Phthalimidehy... CAS#:134724-87-1 |
Literature: Journal of the American Chemical Society, , vol. 133, # 19 p. 7469 - 7475 |
~% 2-Phthalimidehy... CAS#:134724-87-1 |
Literature: US2012/322978 A1, ; |
Precursor 3 | |
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DownStream 0 |
N-(Phth)-AOGly-OH |
phthalmidooxyacetic acid |
PhthN-O-Gly-OH |
2-((1,3-dioxoisoindolin-2-yl)oxy)acetic acid |
phthalimidooxyacetic acid |
phthalimido-aminooxyacetic acid |
Pht-Aoaa-OH |
Acetic acid,[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy] |