Boc-trans-D-Hyp-OMe

Modify Date: 2024-01-03 17:44:03

Boc-trans-D-Hyp-OMe structure	Common Name	Boc-trans-D-Hyp-OMe
	CAS Number	135042-17-0	Molecular Weight	245.272
	Density	1.3±0.1 g/cm3	Boiling Point	387.6±42.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₉NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	188.2±27.9 °C

Use of Boc-trans-D-Hyp-OMe

Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	(2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
Synonym	More Synonyms

Description	Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	387.6±42.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₉NO₅
Molecular Weight	245.272
Flash Point	188.2±27.9 °C
Exact Mass	245.126328
PSA	76.07000
LogP	-0.17
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.520
Storage condition	2-8°C

Hazard Codes	Xi

Precursor 0
DownStream 5
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