tans-4-Hydroxy-D-proline hydrochloride

Modify Date: 2024-01-17 18:17:40

tans-4-Hydroxy-D-proline hydrochloride structure	Common Name	tans-4-Hydroxy-D-proline hydrochloride
	CAS Number	142347-81-7	Molecular Weight	167.591
	Density	N/A	Boiling Point	368.6ºC at 760mmHg
	Molecular Formula	C₅H₁₀ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	176.7ºC

Use of tans-4-Hydroxy-D-proline hydrochloride

tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR

Name	trans-4-Hydroxy-D-proline hydrochloride
Synonym	More Synonyms

Description	tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Boiling Point	368.6ºC at 760mmHg
Molecular Formula	C₅H₁₀ClNO₃
Molecular Weight	167.591
Flash Point	176.7ºC
Exact Mass	167.034927
PSA	69.56000
Vapour Pressure	6.22E-07mmHg at 25°C

Hazard Codes	Xi

Boc-trans-D-Hyp-OMe

CAS#:135042-17-0

~69%

tans-4-Hydroxy-...

CAS#:142347-81-7

Literature: Pandey, Anil K.; Naduthambi, Devan; Thomas, Krista M.; Zondlo, Neal J. Journal of the American Chemical Society, 2013 , vol. 135, # 11 p. 4333 - 4363