DBCO-acid

Modify Date: 2024-01-03 12:42:51

DBCO-acid Structure
DBCO-acid structure
Common Name DBCO-acid
CAS Number 1353016-70-2 Molecular Weight 305.32700
Density N/A Boiling Point N/A
Molecular Formula C19H15NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DBCO-acid


DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1].

 Names

Name 4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoic acid
Synonym More Synonyms

 DBCO-acid Biological Activity

Description DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1].
Related Catalog
Target

Cleavable

References

[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.

 Chemical & Physical Properties

Molecular Formula C19H15NO3
Molecular Weight 305.32700
Exact Mass 305.10500
PSA 57.61000
LogP 2.86280

 Synonyms

DBCO acid 1
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