BQ-123

Modify Date: 2024-01-13 10:58:03

BQ-123 Structure
BQ-123 structure
 Common Name BQ-123
CAS Number 136553-81-6 Molecular Weight 610.701
Density 1.3±0.1 g/cm3 Boiling Point 1053.6±65.0 °C at 760 mmHg
Molecular Formula C31H42N6O7 Melting Point N/A
MSDS Chinese USA Flash Point 591.0±34.3 °C

 Use of BQ-123


BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.

 Names

Name bq-123
Synonym More Synonyms

 BQ-123 Biological Activity

Description BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
Related Catalog
References

[1]. Olgun NS et al. BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicol Appl Pharmacol, 2015 Feb 1;282(3):275-84.

[2]. Kanashiro A et al. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Res, 2015 Jun 12, 1610:12-9.

[3]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1053.6±65.0 °C at 760 mmHg
Molecular Formula C31H42N6O7
Molecular Weight 610.701
Flash Point 591.0±34.3 °C
Exact Mass 610.311523
PSA 189.80000
LogP -0.10
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.621
Storage condition -20℃

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport

 Articles41

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Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation.

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An ischemic-type biliary stricture (ITBS) is a common feature after liver transplantation using donation after cardiac death (DCD) grafts. We compared sequential subnormothermic ex vivo liver perfusio...

Gene expression profiling and endothelin in acute experimental pancreatitis.

World J. Gastroenterol. 18(32) , 4257-69, (2012)

To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.Dibutyltin dichloride (DBTC) is a c...

 Synonyms

Cyclo(L-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
d-trp-d-asp-pro-d-val-leu
bq-518
MFCD00133204
BQ-123
m.w. 610.70 c31h42n6o7
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Chemsrc provides BQ-123(CAS#:136553-81-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BQ-123 are included as well.>> amp version: BQ-123

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