Cap-dependent endonuclease-IN-26
Modify Date: 2024-01-01 19:01:26
Cap-dependent endonuclease-IN-26 structure
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Common Name | Cap-dependent endonuclease-IN-26 | ||
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| CAS Number | 1370238-26-8 | Molecular Weight | 389.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cap-dependent endonuclease-IN-26Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains[1]. |
| Name | Cap-dependent endonuclease-IN-26 |
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| Description | Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains[1]. |
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| Related Catalog | |
| In Vitro | Cap-dependent endonuclease-IN-26 (compound 2v) exhibits broad antiviral spectrum. Cap-dependent endonuclease-IN-26 shows antiviral activity against the H1N1 type, including the reverse genetic strain (rgA/WSN/33), oseltamivir-resistant strain (rgA/WSN/33-NA/H274Y), clinically isolated strain (A/PR/8/34), H3N2 A/Victoria/3/75, H3N2 A/HongKong/8/68, influenza B/Hong Kong/5/72, and influenza B/Maryland/1/59 with EC50 values 165.1 nM, 80.4 nM, 183.0 nM, 828.8 nM, 301.5 nM, 124.3 nM, and 176.0 nM, respectively[1]. |
| In Vivo | In rats, Cap-dependent endonuclease-IN-26 (compound 2v) exhibits reasonable in vivo clearance with 10.9 mL/min/kg[1]. In a mouse influenza B (B/Maryland/1/59) model, Cap-dependent endonuclease-IN-26 (compound 2v; intravenous administration; 0.08-10 mg/kg; q.d.;1 day) shows dose-dependent efficacy in an immediate treatment model[1]. |
| References |
| Molecular Formula | C23H23N3O3 |
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| Molecular Weight | 389.45 |