SRT3657
Modify Date: 2024-02-12 21:33:56
SRT3657 structure
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Common Name | SRT3657 | ||
|---|---|---|---|---|
| CAS Number | 1383551-17-4 | Molecular Weight | 774.97 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H54N8O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRT3657SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1]. |
| Name | SRT3657 |
|---|
| Description | SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1]. |
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| Related Catalog | |
| Target |
SIRT1[1] |
| In Vivo | SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1]. SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1]. SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1]. Animal Model: Adult double-transgenic CK-p25 mice (3-month-old)[1] Dosage: 30 mg/kg Administration: Oral gavage, daily, for 6 weeks Result: Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals. |
| References |
| Molecular Formula | C40H54N8O6S |
|---|---|
| Molecular Weight | 774.97 |