2-Amino-5-methylthiophene-3-carbonitrile

Modify Date: 2024-01-02 20:14:31

2-Amino-5-methylthiophene-3-carbonitrile Structure
2-Amino-5-methylthiophene-3-carbonitrile structure
Common Name 2-Amino-5-methylthiophene-3-carbonitrile
CAS Number 138564-58-6 Molecular Weight 138.190
Density 1.3±0.1 g/cm3 Boiling Point 318.5±42.0 °C at 760 mmHg
Molecular Formula C6H6N2S Melting Point 101-103ºC
MSDS USA Flash Point 146.4±27.9 °C

 Use of 2-Amino-5-methylthiophene-3-carbonitrile


2-Amino-5-methylthiophene-3-carbonitrile can be used in the synthesis of Olanzapine (HY-14541)[1].

 Names

Name 2-Amino-5-methyl-3-thiophenecarbonitrile
Synonym More Synonyms

 2-Amino-5-methylthiophene-3-carbonitrile Biological Activity

Description 2-Amino-5-methylthiophene-3-carbonitrile can be used in the synthesis of Olanzapine (HY-14541)[1].
Related Catalog
References

[1]. Saadatjoo N, et al. Synthesis of the olanzapine labeled by carbon-14. J Labelled Comp Radiopharm. 2016 Jun 30;59(8):325-7.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 318.5±42.0 °C at 760 mmHg
Melting Point 101-103ºC
Molecular Formula C6H6N2S
Molecular Weight 138.190
Flash Point 146.4±27.9 °C
Exact Mass 138.025162
PSA 78.05000
LogP 2.01
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.605

 Safety Information

Hazard Codes Xi
Risk Phrases R20/21/22
Safety Phrases S22-S36/37/39
RIDADR UN 3276
HS Code 2934999090

 Synthetic Route

~76%

2-Amino-5-methylthiophene-3-carbonitrile Structure

2-Amino-5-methy...

CAS#:138564-58-6

Literature: RAMOT AT TEL-AVIV UNIVERSITY LTD Patent: WO2008/50341 A2, 2008 ; Location in patent: Page/Page column 32; 33 ;

~%

2-Amino-5-methylthiophene-3-carbonitrile Structure

2-Amino-5-methy...

CAS#:138564-58-6

Literature: US2009/5556 A1, ; Page/Page column 5 ;

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-Thiophenecarbonitrile, 2-amino-5-methyl-
MFCD01626055
2-Amino-5-methyl-3-thiophenecarbonitrile
T5SJ BZ CCN E1
2-Amino-3-cyano-5-methylthiophene
2-Amino-5-methylthiophene-3-carbonitrile
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