GNE 2861

Modify Date: 2024-09-19 17:33:04

GNE 2861 Structure
GNE 2861 structure
Common Name GNE 2861
CAS Number 1394121-05-1 Molecular Weight 406.48
Density N/A Boiling Point N/A
Molecular Formula C22H26N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GNE 2861


PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

 Names

Name PAK-IN-1

 GNE 2861 Biological Activity

Description PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.
Related Catalog
Target

IC50: 7.5 nM (PAK4), 36 nM (PAK5), 126 nM (PAK6)[1]

In Vitro PAK-IN-1 is compound 4 from the reference[1].
References

[1]. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.

 Chemical & Physical Properties

Molecular Formula C22H26N6O2
Molecular Weight 406.48
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