ADAMTS-5 inhibitor 8
Modify Date: 2024-11-30 11:23:53
ADAMTS-5 inhibitor 8 structure
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Common Name | ADAMTS-5 inhibitor 8 | ||
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| CAS Number | 1394122-20-3 | Molecular Weight | 624.844 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 821.9±75.0 °C at 760 mmHg | |
| Molecular Formula | C29H36N8O2S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 450.8±37.1 °C | |
Use of ADAMTS-5 inhibitor 8ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. |
| Name | N-({(2R)-1-[4-(3-Buten-1-ylamino)-6-({[2-(2-thienyl)-1,3-thiazol-4-yl]methyl}amino)-1,3,5-triazin-2-yl]-2-pyrrolidinyl}methyl)-4-propylbenzenesulfonamide |
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| Synonym | More Synonyms |
| Description | ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. |
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| References | References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 821.9±75.0 °C at 760 mmHg |
| Molecular Formula | C29H36N8O2S3 |
| Molecular Weight | 624.844 |
| Flash Point | 450.8±37.1 °C |
| Exact Mass | 624.212341 |
| LogP | 4.46 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.641 |
| N-({(2R)-1-[4-(3-Buten-1-ylamino)-6-({[2-(2-thienyl)-1,3-thiazol-4-yl]methyl}amino)-1,3,5-triazin-2-yl]-2-pyrrolidinyl}methyl)-4-propylbenzenesulfonamide |
| Benzenesulfonamide, N-[[(2R)-1-[4-(3-buten-1-ylamino)-6-[[[2-(2-thienyl)-4-thiazolyl]methyl]amino]-1,3,5-triazin-2-yl]-2-pyrrolidinyl]methyl]-4-propyl- |