SUVN-G3031
Modify Date: 2024-01-13 18:48:50
SUVN-G3031 structure
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Common Name | SUVN-G3031 | ||
|---|---|---|---|---|
| CAS Number | 1394808-82-2 | Molecular Weight | 373.489 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 562.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H31N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 294.0±30.1 °C | |
Use of SUVN-G3031SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical |
| Name | Suvn-G3031 |
|---|---|
| Synonym | More Synonyms |
| Description | SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical |
|---|---|
| References | References 1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280. View Related Products by Target Histamine Receptor Parkinson Disease |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 562.4±50.0 °C at 760 mmHg |
| Molecular Formula | C21H31N3O3 |
| Molecular Weight | 373.489 |
| Flash Point | 294.0±30.1 °C |
| Exact Mass | 373.236542 |
| LogP | 2.56 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.597 |
| N-{4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl}-2-(4-morpholinyl)acetamide |
| 4-Morpholineacetamide, N-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]- |
| Suvn-G3031 |