1791396-46-7

1791396-46-7 structure

Name: SUVN-502 mesylate
Chemical Name: Masupirdine mesylate
CAS Number: 1791396-46-7
Molecular Formula: C₂₃H₃₂BrN₃O₉S₃
Molecular Weight: 670.61
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2019-10-07 13:47:19
Modify Date: 2024-01-12 21:40:46
Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].

Name	Masupirdine mesylate

Description	Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT6 Receptor:2.04 nM (Ki)
References	[1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.

Molecular Formula	C₂₃H₃₂BrN₃O₉S₃
Molecular Weight	670.61