701205-60-9

701205-60-9 structure

Name: SUVN-502
Chemical Name: Masupirdine free base
CAS Number: 701205-60-9
Molecular Formula: C₂₁H₂₄BrN₃O₃S
Molecular Weight: 478.40
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2019-09-07 09:11:16
Modify Date: 2024-01-30 00:23:33
Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].

Name	Masupirdine free base

Description	Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Ki: 2.04 nM (human 5-HT6 receptor)[1]
References	[1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.

Molecular Formula	C₂₁H₂₄BrN₃O₃S
Molecular Weight	478.40