2-(Azido-PEG2-amido)-1,3-propandiol

Modify Date: 2024-01-02 18:18:48

2-(Azido-PEG2-amido)-1,3-propandiol Structure
2-(Azido-PEG2-amido)-1,3-propandiol structure
Common Name 2-(Azido-PEG2-amido)-1,3-propandiol
CAS Number 1398044-52-4 Molecular Weight 276.290
Density N/A Boiling Point N/A
Molecular Formula C10H20N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-(Azido-PEG2-amido)-1,3-propandiol


2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-(Azido-PEG2-amido)-1,3-propandiol
Synonym More Synonyms

 2-(Azido-PEG2-amido)-1,3-propandiol Biological Activity

Description 2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C10H20N4O5
Molecular Weight 276.290
Exact Mass 276.143372
LogP -1.82

 Synonyms

MFCD22574770
Propanamide, 3-[2-(2-azidoethoxy)ethoxy]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-
3-[2-(2-Azidoethoxy)ethoxy]-N-(1,3-dihydroxy-2-propanyl)propanamide
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