1398044-52-4

1398044-52-4 structure

Name: 2-(Azido-PEG2-amido)-1,3-propandiol
Chemical Name: 2-(Azido-PEG2-amido)-1,3-propandiol
CAS Number: 1398044-52-4
Molecular Formula: C₁₀H₂₀N₄O₅
Molecular Weight: 276.290
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-12 10:44:24
Modify Date: 2024-01-02 18:18:48
2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(Azido-PEG2-amido)-1,3-propandiol
Synonyms	MFCD22574770 Propanamide, 3-[2-(2-azidoethoxy)ethoxy]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]- 3-[2-(2-Azidoethoxy)ethoxy]-N-(1,3-dihydroxy-2-propanyl)propanamide

Description	2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562