ATPA

Modify Date: 2024-01-04 23:38:54

ATPA structure	Common Name	ATPA
	CAS Number	140158-50-5	Molecular Weight	228.24500
	Density	1.264g/cm3	Boiling Point	406.8ºC at 760mmHg
	Molecular Formula	C₁₀H₁₆N₂O₄	Melting Point	N/A
	MSDS	Chinese	Flash Point	199.9ºC

Use of ATPA

ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively[1].

Name	ATPA,(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoicacid
Synonym	More Synonyms

Description	ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	ATPA also activates GluR1wt, GluR1(M722S), GluR1(T700S), GluR1(T700S, M722S), GluR1(M722A) with EC50s of 62, 4.6, 97, 14, 97 μM, respectively[1].
References	[1]. Nielsen MM, et al. The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. Mol Pharmacol. 2003 Jan;63(1):19-25.

Density	1.264g/cm3
Boiling Point	406.8ºC at 760mmHg
Molecular Formula	C₁₀H₁₆N₂O₄
Molecular Weight	228.24500
Flash Point	199.9ºC
Exact Mass	228.11100
PSA	109.58000
LogP	1.33240
Vapour Pressure	2.38E-07mmHg at 25°C
Index of Refraction	1.529

N/A structure

N/A

CAS#:95406-73-8

~77%

ATPA Structure

ATPA

CAS#:140158-50-5

Literature: Lauridsen, Joern; Honore, Tage; Krogsgaard-Larsen, Povl Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 668 - 672

ethyl 4,4,4-trimethylacetoacetate structure

ethyl 4,4,4-tri...

CAS#:17094-34-7

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ATPA Structure

ATPA

CAS#:140158-50-5

Literature: Lauridsen, Joern; Honore, Tage; Krogsgaard-Larsen, Povl Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 668 - 672

5-tert-butyl-4-hydroxymethyl-3-methoxyisoxazole structure

5-tert-butyl-4-...

CAS#:252354-17-9

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ATPA Structure

ATPA

CAS#:140158-50-5

Literature: Johansen, Tommy N.; Hawes, Calvin R.; Ellis, Gareth J.; Ebert, Bjarke; Stensbol, Tine B.; Da Graca Thrige, Dorthe; Krogsgaard-Larsen, Povl Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 937 - 947

5-tert-butyl-4-chloromethyl-3-methoxyisoxazole structure

5-tert-butyl-4-...

CAS#:252354-20-4

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ATPA Structure

ATPA

CAS#:140158-50-5

Literature: Johansen, Tommy N.; Hawes, Calvin R.; Ellis, Gareth J.; Ebert, Bjarke; Stensbol, Tine B.; Da Graca Thrige, Dorthe; Krogsgaard-Larsen, Povl Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 937 - 947

2,4-bis(bromomethyl)-5-(tert-butyl)isoxazol-3(2H)-one structure

2,4-bis(bromome...

CAS#:1027496-30-5

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ATPA Structure

ATPA

CAS#:140158-50-5

Literature: Slok; Ebert; Lang; Krogsgaard-Larsen; Lenz; Madsen European Journal of Medicinal Chemistry, 1997 , vol. 32, # 4 p. 329 - 338

4-bromomethyl-2-methoxymethyl-5-tert-butylisoxazolin-3-one structure

4-bromomethyl-2...

CAS#:192439-80-8

~%

ATPA Structure

ATPA

CAS#:140158-50-5

Literature: Slok; Ebert; Lang; Krogsgaard-Larsen; Lenz; Madsen European Journal of Medicinal Chemistry, 1997 , vol. 32, # 4 p. 329 - 338

Precursor 1
CAS#:17094-34-7 ethyl 4,4,4-tri...
DownStream 0

16,16-Dimethyl Prostaglandin E2

ATPA

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ATPA
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ATPA
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: ATPA
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥2100/1 mg

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