IS-741
Modify Date: 2024-01-13 19:13:11
IS-741 structure
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Common Name | IS-741 | ||
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| CAS Number | 141283-87-6 | Molecular Weight | 379.39800 | |
| Density | 1.411g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H20F3N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IS-741Fuzapladib (IS-741) is a potent phospholipase A2 inhibitor. Fuzapladib can block the adhesion of inflammatory cells to microvascular endothelial cells, inhibit the infiltration of neutrophils into the pancreas or acute pancreatitis, and has anti-acute pancreatitis effects[1]. |
| Name | N-[2-(ethylsulfonylamino)-5-(trifluoromethyl)pyridin-3-yl]cyclohexanecarboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | Fuzapladib (IS-741) is a potent phospholipase A2 inhibitor. Fuzapladib can block the adhesion of inflammatory cells to microvascular endothelial cells, inhibit the infiltration of neutrophils into the pancreas or acute pancreatitis, and has anti-acute pancreatitis effects[1]. |
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| Related Catalog | |
| In Vitro | Fuzapladib(IS-741)(1 μM, 3 h)在脂多糖刺激下，可显着抑制 HL-60 细胞与 HUVEC 的粘附[1]。 |
| In Vivo | Fuzapladib(IS-741)(p.o., 50 mg/kg, 7 days) 显着降低了大鼠回肠中的髓过氧化物酶 (MPO) 活性和粘膜 IL-8 水平，减少了多形核细胞和 Mac-1 阳性细胞向发炎病灶的浸润，有效减轻了三硝基苯磺酸(TNBS)诱导的大鼠回肠炎[2]。 |
| References |
| Density | 1.411g/cm3 |
|---|---|
| Molecular Formula | C15H20F3N3O3S |
| Molecular Weight | 379.39800 |
| Exact Mass | 379.11800 |
| PSA | 100.03000 |
| LogP | 5.18410 |
| Index of Refraction | 1.548 |
| IS 741 |
| N-(2-((Ethylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)cyclohexanecarboxamide |
| Cyclohexanecarboxamide,N-(2-((ethylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl) |