NSC 45576

Modify Date: 2024-02-28 15:09:01

NSC 45576 Structure
NSC 45576 structure
Common Name NSC 45576
CAS Number 1414586-62-1 Molecular Weight 378.402
Density N/A Boiling Point N/A
Molecular Formula C20H14N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NSC 45576


NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM; inhibits cAMP-induced EPAC activation while not affecting PKA activity; a valuable pharmacological tools for elucidating the biological functions of EPAC and for promoting an understanding of disease mechanisms related to EPAC/cAMP signaling.

 Names

Name NSC 45576

 NSC 45576 Biological Activity

Description NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM; inhibits cAMP-induced EPAC activation while not affecting PKA activity; a valuable pharmacological tools for elucidating the biological functions of EPAC and for promoting an understanding of disease mechanisms related to EPAC/cAMP signaling.
References References 1. Tsalkova T, et al. PLoS One. 2012;7(1):e30441. 2. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65. 3. Mizuta K, et al. Respir Res. 2013 Sep 2;14:89. View Related Products by Target Other Targets

 Chemical & Physical Properties

Molecular Formula C20H14N2O4S
Molecular Weight 378.402
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