Melanin probe-1
Modify Date: 2024-01-16 14:18:10
Melanin probe-1 structure
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Common Name | Melanin probe-1 | ||
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| CAS Number | 1420844-62-7 | Molecular Weight | 239.29 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H18FN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Melanin probe-1Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1]. |
| Name | Melanin probe-1 |
|---|
| Description | Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1]. |
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| Related Catalog | |
| In Vivo | Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency[1]. Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection[1]. Animal Model: C57BL/6 mice bearing B16F10 murine melanomas[1] Dosage: 3.7 MBq (100 μCi) Administration: Tail vein Result: The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively. |
| References |
| Molecular Formula | C12H18FN3O |
|---|---|
| Molecular Weight | 239.29 |
| Storage condition | 2-8°C |