Boc-O1Pen-OH * DCHA

Modify Date: 2024-01-05 14:11:42

Boc-O1Pen-OH * DCHA structure	Common Name	Boc-O1Pen-OH * DCHA
	CAS Number	142929-49-5	Molecular Weight	219.235
	Density	1.2±0.1 g/cm3	Boiling Point	391.2±22.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₇NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	190.4±22.3 °C

Use of Boc-O1Pen-OH * DCHA

Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]acetic acid
Synonym	More Synonyms

Description	Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.2±0.1 g/cm3
Boiling Point	391.2±22.0 °C at 760 mmHg
Molecular Formula	C₉H₁₇NO₅
Molecular Weight	219.235
Flash Point	190.4±22.3 °C
Exact Mass	219.110672
PSA	84.86000
LogP	0.55
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.462

HS Code	2924199090

Boc-NH-PEG1-OH

CAS#:26690-80-2

Chloroacetic acid

CAS#:79-11-8

~71%

Boc-O1Pen-OH * DCHA

CAS#:142929-49-5

Literature: MYREXIS, INC.; BAJJI, Ashok, C.; TANGALLAPALLY, Rajendra, P.; KIM, In, Chul; KIM, Se, Ho; PARKER, Daniel, P.; TROVATO, Richard; PAPAC, Damon, I.; YAGER, Kraig; BAICHWAL, Vijay, R. Patent: WO2012/148550 A1, 2012 ; Location in patent: Page/Page column 50; 51 ;

4-MORPHOLINECAR...

CAS#:142929-48-4

~71%

Boc-O1Pen-OH * DCHA

CAS#:142929-49-5

Literature: Chandrakumar; Stapelfeld; Beardsley; Lopez; Drury; Anthony; Savage; Williamson; Reichman Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2928 - 2938

N/A

CAS#:142929-50-8

~75%

Boc-O1Pen-OH * DCHA

CAS#:142929-49-5

Literature: Adamczyk, Maciej; Fishpaugh, Jeffrey R.; Thiruvazhi, Mohan Organic Preparations and Procedures International, 2002 , vol. 34, # 3 p. 326 - 331

Di-tert-butyl d...

CAS#:24424-99-5

Boc-O1Pen-OH * DCHA

CAS#:142929-49-5

Literature: Journal of Medicinal Chemistry, , vol. 35, # 16 p. 2928 - 2938

Boc-NH-PEG1-OH

CAS#:26690-80-2

Boc-O1Pen-OH * DCHA

CAS#:142929-49-5

Literature: Organic Preparations and Procedures International, , vol. 34, # 3 p. 326 - 331

Precursor 3
CAS#:26690-80-2 Boc-NH-PEG1-OH CAS#:79-11-8 Chloroacetic acid CAS#:24424-99-5 Di-tert-butyl d...
DownStream 0

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%