JAK3-IN-12

Modify Date: 2024-01-16 22:16:11

JAK3-IN-12 structure	Common Name	JAK3-IN-12
	CAS Number	1430095-86-5	Molecular Weight	413.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₉N₅O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK3-IN-12

JAK3-IN-12 (compound 15k) is a highly potent JAK3 inhibitor with an IC50 value of 9.5 nM. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

Name	JAK3-IN-12

Description	JAK3-IN-12 (compound 15k) is a highly potent JAK3 inhibitor with an IC50 value of 9.5 nM. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK3:9.5 nM (IC50)
In Vivo	Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1]. IV (1 mg/kg); PO (3 mg/kg) Tmax (h) 0.5 Cmax (ng/ml) 146±48 tmax (h) 1.85±0.43 CL (mL/min/kg), iv 40.37 ± 3.61 AUC0-α (μg/mL·h) 192 ± 56 F (%) 15
References	[1]. Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.

Molecular Formula	C₁₉H₁₉N₅O₄S
Molecular Weight	413.45