L 012 sodium salt

Modify Date: 2024-01-11 20:06:09

L 012 sodium salt Structure
L 012 sodium salt structure
Common Name L 012 sodium salt
CAS Number 143556-24-5 Molecular Weight 310.671
Density N/A Boiling Point N/A
Molecular Formula C13H8ClN4NaO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L 012 sodium salt


L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors[1].

 Names

Name L 012 sodium salt
Synonym More Synonyms

 L 012 sodium salt Biological Activity

Description L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors[1].
Related Catalog
In Vitro L-012 sodium salt, a chemical analog of luminol, gives rise to significantly higher luminescence yield and increased sensitivity as compared to other CL probes, lucigenin and MCLA[1].
In Vivo L-012 sodium salt is well distributed in the mouse body and mediates a strong ROS/RNS-dependent luminescent signal in vivo and is useful for monitoring the development and regulation of inflammation in living organisms[2].
References

[1]. Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314.

[2]. Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47(6):760-766.

 Chemical & Physical Properties

Molecular Formula C13H8ClN4NaO2
Molecular Weight 310.671
Exact Mass 310.023346

 Synonyms

MFCD30378369
MFCD27991293
Pyrido[3,4-d]pyridazin-1(2H)-one, 8-amino-5-chloro-4-hydroxy-7-phenyl-, sodium salt (1:1)
Sodium 8-amino-5-chloro-1-oxo-7-phenyl-1,2-dihydropyrido[3,4-d]pyridazin-4-olate
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Price: ¥1650/10 mM * 1 mL in DMSO

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