143556-24-5

143556-24-5 structure

Name: L 012 sodium salt
Chemical Name: L 012 sodium salt
CAS Number: 143556-24-5
Molecular Formula: C₁₃H₈ClN₄NaO₂
Molecular Weight: 310.671
Catalog: Research Areas Inflammation/Immunology
Create Date: 2021-05-06 11:05:49
Modify Date: 2024-01-11 20:06:09
L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors[1].

Name	L 012 sodium salt
Synonyms	MFCD30378369 MFCD27991293 Pyrido[3,4-d]pyridazin-1(2H)-one, 8-amino-5-chloro-4-hydroxy-7-phenyl-, sodium salt (1:1) Sodium 8-amino-5-chloro-1-oxo-7-phenyl-1,2-dihydropyrido[3,4-d]pyridazin-4-olate

Description	L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	L-012 sodium salt, a chemical analog of luminol, gives rise to significantly higher luminescence yield and increased sensitivity as compared to other CL probes, lucigenin and MCLA[1].
In Vivo	L-012 sodium salt is well distributed in the mouse body and mediates a strong ROS/RNS-dependent luminescent signal in vivo and is useful for monitoring the development and regulation of inflammation in living organisms[2].
References	[1]. Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314. [2]. Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47(6):760-766.