N,N’-(3-Fluoro-4-Methyl-8-Oxo-5,6,7,8-Tetrahydronaphthalene-1,7-Diyl)Diacetamide

Modify Date: 2024-10-05 18:11:19

N,N’-(3-Fluoro-4-Methyl-8-Oxo-5,6,7,8-Tetrahydronaphthalene-1,7-Diyl)Diacetamide structure	Common Name	N,N’-(3-Fluoro-4-Methyl-8-Oxo-5,6,7,8-Tetrahydronaphthalene-1,7-Diyl)Diacetamide
	CAS Number	143655-70-3	Molecular Weight	292.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₇FN₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N,N’-(3-Fluoro-4-Methyl-8-Oxo-5,6,7,8-Tetrahydronaphthalene-1,7-Diyl)Diacetamide

Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).

Name	N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide

Description	Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10. [2]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

Description

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

References

[1]. Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.

[2]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

Molecular Formula	C₁₅H₁₇FN₂O₃
Molecular Weight	292.31

N,N’-(3-Fluoro-4-Methyl-8-Oxo-5,6,7,8-Tetrahydronaphthalene-1,7-Diyl)Diacetamide

Use of N,N’-(3-Fluoro-4-Methyl-8-Oxo-5,6,7,8-Tetrahydronaphthalene-1,7-Diyl)Diacetamide

Names

Biological Activity

Chemical & Physical Properties