sulfacetamide

Modify Date: 2024-01-02 16:06:26

sulfacetamide Structure
sulfacetamide structure
 Common Name sulfacetamide
CAS Number 144-80-9 Molecular Weight 214.242
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C8H10N2O3S Melting Point 182-184 °C
MSDS Chinese USA Flash Point N/A

 Use of sulfacetamide


Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections[1][2].

 Names

Name sulfacetamide
Synonym More Synonyms

 sulfacetamide Biological Activity

Description Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections[1][2].
Related Catalog
References

[1]. D Smit. Anti-infective ophthalmic preparations in general practice, South African Family Practice, 54:4, 302-307.

[2]. N. Rajesh Goud,et al. Modulating the solubility of sulfacetamide by means of cocrystals†

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 182-184 °C
Molecular Formula C8H10N2O3S
Molecular Weight 214.242
Exact Mass 214.041214
PSA 97.64000
LogP -0.96
Vapour Pressure 0.04mmHg at 25°C
Index of Refraction 1.584
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.
Water Solubility <0.01 g/100 mL at 16 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8450000
CHEMICAL NAME :
Acetamide, N-sulfanilyl-
CAS REGISTRY NUMBER :
144-80-9
BEILSTEIN REFERENCE NO. :
0981718
LAST UPDATED :
199701
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C8-H10-N2-O3-S
MOLECULAR WEIGHT :
214.26
WISWESSER LINE NOTATION :
ZR DSWMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
606 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 gm/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
1 gm/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80537 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80537 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1639 (estimated) No. of Female Employees: 1344 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R20/21/22
Safety Phrases S22-S24/25
RIDADR 3249
WGK Germany 2
RTECS AC8450000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2935009090

 Synthetic Route

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles56

More Articles
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Simultaneous determination of sulfonamides and metabolites in manure samples by one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction and liquid chromatography-mass spectrometry.

Anal. Bioanal. Chem 407(13) , 3545-54, (2015)

An in-line matrix cleanup method was used for the simultaneous extraction of 15 sulfonamides and two metabolites from manure samples. The ultrasound/microwave-assisted extraction (UMAE) combined with ...

Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.

Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015)

This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The resul...

 Synonyms

A-500
N-(4-Aminobenzenesulfonyl)acetamide (N-(4-Aminophenylsulfonyl)acetamide
Solfacetamide [DCIT]
Alesten
EINECS 205-640-6
Acetocid
Oclucid
Sulamyd
N-[(4-Aminophenyl)sulfonyl]acetamide
sulfacetamidum
ALBUCID SOLUBLE
Acetamide, N-[(4-aminophenyl)sulfonyl]-
N-Acetylsulfanilamide
Sebizon
sultrin
N1-acetylsulfanilamide
I-Sulfacet
Prontamid
Sulfacet
Sulfair
Acetamide, N-((4-aminophenyl)sulfonyl)-
Isopto-Cetamide
N-acetyl-4-aminobenzenesulfonamide
sulfacetamide
Locula
Ak-Sulf
sulfacetamida
N-((4-Aminophenyl)sulfonyl)acetamide
Sulfacetimide
Region
Beocid-isoptal
Antebor
Albucid
MFCD00066501
Sulf-10
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