sulfacetamide

Modify Date: 2024-01-02 16:06:26

sulfacetamide structure	Common Name	sulfacetamide
	CAS Number	144-80-9	Molecular Weight	214.242
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₈H₁₀N₂O₃S	Melting Point	182-184 °C
	MSDS	Chinese USA	Flash Point	N/A

Use of sulfacetamide

Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections[1][2].

Name	sulfacetamide
Synonym	More Synonyms

Description	Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. D Smit. Anti-infective ophthalmic preparations in general practice, South African Family Practice, 54:4, 302-307. [2]. N. Rajesh Goud,et al. Modulating the solubility of sulfacetamide by means of cocrystals†

Description

Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections[1][2].

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. D Smit. Anti-infective ophthalmic preparations in general practice, South African Family Practice, 54:4, 302-307.

[2]. N. Rajesh Goud,et al. Modulating the solubility of sulfacetamide by means of cocrystals†

Density	1.4±0.1 g/cm3
Melting Point	182-184 °C
Molecular Formula	C₈H₁₀N₂O₃S
Molecular Weight	214.242
Exact Mass	214.041214
PSA	97.64000
LogP	-0.96
Vapour Pressure	0.04mmHg at 25°C
Index of Refraction	1.584
Storage condition	0-6°C
Stability	Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.
Water Solubility	<0.01 g/100 mL at 16 ºC

sulfacetamide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8450000

CHEMICAL NAME :: Acetamide, N-sulfanilyl-

CAS REGISTRY NUMBER :: 144-80-9

BEILSTEIN REFERENCE NO. :: 0981718

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C8-H10-N2-O3-S

MOLECULAR WEIGHT :: 214.26

WISWESSER LINE NOTATION :: ZR DSWMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 606 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 1 gm/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80537 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80537 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1639 (estimated) No. of Female Employees: 1344 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R20/21/22
Safety Phrases	S22-S24/25
RIDADR	3249
WGK Germany	2
RTECS	AC8450000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2935009090

Precursor 9
CAS#:3731-53-1 4-picolinylamine CAS#:121-60-8 4-Acetamidobenz... CAS#:108-24-7 Ethanoic anhydride CAS#:63-74-1 Sulfanilamide
CAS#:5626-90-4 Acetamide,N-[[4... CAS#:121-61-9 4-Acetamidobenz... CAS#:64-19-7 acetic acid CAS#:847507-38-4 N-benzyloxycarb...
CAS#:5768-68-3 Ethanimidamide,...
DownStream 7
CAS#:83796-87-6 Azoxybenzene-4,... CAS#:63-74-1 Sulfanilamide CAS#:4320-29-0 Azobenzene-4,4'... CAS#:2779-21-7 4,4'-Azobis(ben...
CAS#:121-57-3 Sulfanilic acid CAS#:5187-79-1 Azoxybenzene-4,... CAS#:131-69-1 Phthalylsulface...

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Simultaneous determination of sulfonamides and metabolites in manure samples by one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction and liquid chromatography-mass spectrometry.

Anal. Bioanal. Chem 407(13) , 3545-54, (2015)

An in-line matrix cleanup method was used for the simultaneous extraction of 15 sulfonamides and two metabolites from manure samples. The ultrasound/microwave-assisted extraction (UMAE) combined with ...

Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.

Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015)

This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The resul...

A-500

N-(4-Aminobenzenesulfonyl)acetamide (N-(4-Aminophenylsulfonyl)acetamide

Solfacetamide [DCIT]

Alesten

EINECS 205-640-6

Acetocid

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Sulamyd

N-[(4-Aminophenyl)sulfonyl]acetamide

sulfacetamidum

ALBUCID SOLUBLE

Acetamide, N-[(4-aminophenyl)sulfonyl]-

N-Acetylsulfanilamide

Sebizon

sultrin

N1-acetylsulfanilamide

I-Sulfacet

Prontamid

Sulfacet

Sulfair

Acetamide, N-((4-aminophenyl)sulfonyl)-

Isopto-Cetamide

N-acetyl-4-aminobenzenesulfonamide

sulfacetamide

Locula

Ak-Sulf

sulfacetamida

N-((4-Aminophenyl)sulfonyl)acetamide

Sulfacetimide

Region

Beocid-isoptal

Antebor

Albucid

MFCD00066501

Sulf-10

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sulfacetamide

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