MM-401

Modify Date: 2024-01-13 08:28:36

MM-401 Structure
MM-401 structure
Common Name MM-401
CAS Number 1442106-10-6 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MM-401


MM-401 is a potent inhibitor for the MLL1-WDR5 interaction with the IC50 of 0.9 nM in disrupting WDR5-MLL1 interaction. MM-401 maintains high binding affinity to WDR5 (Ki<1 nM). MM-401 specifically inhibits MLL1 H3 lysine (K) 4 methyltransferase activity but does not affect other MLL family histone methyltransferases (HMTs). MM-401 can be used for the research of MLL leukemia[1].

 Names

Name MM-401
Synonym More Synonyms

 MM-401 Biological Activity

Description MM-401 is a potent inhibitor for the MLL1-WDR5 interaction with the IC50 of 0.9 nM in disrupting WDR5-MLL1 interaction. MM-401 maintains high binding affinity to WDR5 (Ki<1 nM). MM-401 specifically inhibits MLL1 H3 lysine (K) 4 methyltransferase activity but does not affect other MLL family histone methyltransferases (HMTs). MM-401 can be used for the research of MLL leukemia[1].
Related Catalog
References

[1]. Fang Cao, et al. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell. 2014 Jan 23;53(2):247-61.

 Chemical & Physical Properties

No Any Chemical & Physical Properties

 Synonyms

MM401
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