GEA 3162

Modify Date: 2024-01-29 11:41:32

GEA 3162 Structure
GEA 3162 structure
Common Name GEA 3162
CAS Number 144576-10-3 Molecular Weight 231.04
Density N/A Boiling Point N/A
Molecular Formula C7H4Cl2N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GEA 3162


GEA 3162, oxatriazol derivative, is a NO-releasing compound. GEA 3162 can be used for the research of Inflammation diseases[1].

 Names

Name 3-(3,4-dichlorophenyl)-1-oxa-2-aza-3-azonia-4-azanidacyclopent-2-en-5-imine
Synonym More Synonyms

 GEA 3162 Biological Activity

Description GEA 3162, oxatriazol derivative, is a NO-releasing compound. GEA 3162 can be used for the research of Inflammation diseases[1].
Related Catalog
In Vitro GEA 3162(1-100 μM)抑制 Ca 离子载体 A23187 诱导的 LTB4 和 β-葡萄糖醛酸酶释放、趋化肽 FMLP 诱导的趋化作用和调理酵母聚糖触发的化学发光,剂量依赖性抑制人 PMNs[1]。 GEA 3162 (0-1 mM) 以剂量依赖性方式抑制人体 PMN 释放 LTB4[1]。 GEA 3162(0-1 mM)以剂量依赖性方式抑制 A23187 激活的 PMN 释放 β-葡萄糖醛酸酶[1]。 GEA 3162 (0-1 mM) 是 FMLP 诱导的人类 PMN 趋化运动的有效抑制剂,IC50 值为 6 μM[1]。 GEA 3162 在较低的药物浓度下更快地提高循环 GMP 水平[1]。
References

[1]. Moilanen E, et al. Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br J Pharmacol. 1993;109(3):852-858.  

 Chemical & Physical Properties

Molecular Formula C7H4Cl2N4O
Molecular Weight 231.04
Exact Mass 229.97600
PSA 67.70000
LogP 1.74630

 Synonyms

C7H4Cl2N4O
Gea-3162
GEA 3162
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