144576-10-3

144576-10-3 structure

Name: GEA 3162
Chemical Name: 3-(3,4-dichlorophenyl)-1-oxa-2-aza-3-azonia-4-azanidacyclopent-2-en-5-imine
CAS Number: 144576-10-3
Molecular Formula: C₇H₄Cl₂N₄O
Molecular Weight: 231.04
Create Date: 2016-07-28 07:50:36
Modify Date: 2024-01-29 11:41:32
GEA 3162, oxatriazol derivative, is a NO-releasing compound. GEA 3162 can be used for the research of Inflammation diseases[1].

Name	3-(3,4-dichlorophenyl)-1-oxa-2-aza-3-azonia-4-azanidacyclopent-2-en-5-imine
Synonyms	C7H4Cl2N4O Gea-3162 GEA 3162

Description	GEA 3162, oxatriazol derivative, is a NO-releasing compound. GEA 3162 can be used for the research of Inflammation diseases[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	GEA 3162（1-100 μM）抑制 Ca 离子载体 A23187 诱导的 LTB4 和 β-葡萄糖醛酸酶释放、趋化肽 FMLP 诱导的趋化作用和调理酵母聚糖触发的化学发光，剂量依赖性抑制人 PMNs[1]。 GEA 3162 (0-1 mM) 以剂量依赖性方式抑制人体 PMN 释放 LTB4[1]。 GEA 3162（0-1 mM）以剂量依赖性方式抑制 A23187 激活的 PMN 释放 β-葡萄糖醛酸酶[1]。 GEA 3162 (0-1 mM) 是 FMLP 诱导的人类 PMN 趋化运动的有效抑制剂，IC50 值为 6 μM[1]。 GEA 3162 在较低的药物浓度下更快地提高循环 GMP 水平[1]。
References	[1]. Moilanen E, et al. Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br J Pharmacol. 1993;109(3):852-858.