S-15535
S-15535 structure
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Common Name | S-15535 | ||
|---|---|---|---|---|
| CAS Number | 146998-34-7 | Molecular Weight | 336.42700 | |
| Density | 1.228g/cm3 | Boiling Point | 504.5ºC at 760mmHg | |
| Molecular Formula | C21H24N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 148.9ºC | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of S-15535S-15535 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety[1]. |
| Name | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine |
|---|---|
| Synonym | More Synonyms |
| Description | S-15535 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety[1]. |
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| Related Catalog | |
| Target |
5-HT1A receptor[1]. |
| References |
| Density | 1.228g/cm3 |
|---|---|
| Boiling Point | 504.5ºC at 760mmHg |
| Molecular Formula | C21H24N2O2 |
| Molecular Weight | 336.42700 |
| Flash Point | 148.9ºC |
| Exact Mass | 336.18400 |
| PSA | 24.94000 |
| LogP | 2.75010 |
| Vapour Pressure | 2.63E-10mmHg at 25°C |
| Index of Refraction | 1.628 |
| Storage condition | 2-8℃ |
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S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.
J. Pharmacol. Exp. Ther. 282(1) , 132-47, (1997) The novel, potential anxiolytic, S 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine), is an agonist and antagonist (weak partial agonist) at pre- and postsynaptic serotonin (5-HT)1A receptors, resp... |
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Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.
Br. J. Pharmacol. 132(2) , 518-24, (2001) 1. The interaction of serotonergic ligands at human (h) 5-HT(1A) receptors expressed in Chinese hamster ovary cells was examined with the selective 'neutral' 5-HT(1A) antagonist [(3)H]-WAY100,635. Its... |
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Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.
J. Med. Chem. 45(1) , 165-76, (2002) S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several mo... |
| 4-(Benzodioxan-5-yl)-1-(indan-2-yl)piperazine |
| Piperazine,1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1H-inden-2-yl) |
| 1-(2,3-dihydro-1,4-benzodioxin-8-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine |
| 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: S-15535
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: S15535
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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