1-(2,3-二氢-1,4-苯并二恶英-5-基)-4-(2,3-二氢-1H-茚满-2-基)哌嗪结构式
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常用名 | 1-(2,3-二氢-1,4-苯并二恶英-5-基)-4-(2,3-二氢-1H-茚满-2-基)哌嗪 | 英文名 | S-15535 |
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| CAS号 | 146998-34-7 | 分子量 | 336.42700 | |
| 密度 | 1.228g/cm3 | 沸点 | 504.5ºC at 760mmHg | |
| 分子式 | C21H24N2O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 148.9ºC | |
| 符号 |
GHS09 |
信号词 | Warning |
用途S-15535 是一种具有高选择性的 5-HT1A 受体配体。S-15535 是突触后 5-HT1A 受体的拮抗剂,也是突触前 5-HT1A 受体的激动剂。S-15535 可用于精神疾病的研究,如抗焦虑。 |
| 中文名 | 1-(2,3-二氢-1,4-苯并二恶英-5-基)-4-(2,3-二氢-1H-茚满-2-基)哌嗪 |
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| 英文名 | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine |
| 英文别名 | 更多 |
| 描述 | S-15535 是一种具有高选择性的 5-HT1A 受体配体。S-15535 是突触后 5-HT1A 受体的拮抗剂,也是突触前 5-HT1A 受体的激动剂。S-15535 可用于精神疾病的研究,如抗焦虑。 |
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| 相关类别 | |
| 靶点 |
5-HT1A receptor[1]. |
| 参考文献 |
| 密度 | 1.228g/cm3 |
|---|---|
| 沸点 | 504.5ºC at 760mmHg |
| 分子式 | C21H24N2O2 |
| 分子量 | 336.42700 |
| 闪点 | 148.9ºC |
| 精确质量 | 336.18400 |
| PSA | 24.94000 |
| LogP | 2.75010 |
| 外观性状 | 白色固体 |
| 蒸汽压 | 2.63E-10mmHg at 25°C |
| 折射率 | 1.628 |
| 储存条件 | 2-8℃ |
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S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.
J. Pharmacol. Exp. Ther. 282(1) , 132-47, (1997) The novel, potential anxiolytic, S 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine), is an agonist and antagonist (weak partial agonist) at pre- and postsynaptic serotonin (5-HT)1A receptors, resp... |
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Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.
Br. J. Pharmacol. 132(2) , 518-24, (2001) 1. The interaction of serotonergic ligands at human (h) 5-HT(1A) receptors expressed in Chinese hamster ovary cells was examined with the selective 'neutral' 5-HT(1A) antagonist [(3)H]-WAY100,635. Its... |
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Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.
J. Med. Chem. 45(1) , 165-76, (2002) S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several mo... |
| 4-(Benzodioxan-5-yl)-1-(indan-2-yl)piperazine |
| Piperazine,1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1H-inden-2-yl) |
| 1-(2,3-dihydro-1,4-benzodioxin-8-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine |
| 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine |
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