Niraparib metabolite M1

Modify Date: 2024-01-06 17:17:05

Niraparib metabolite M1 Structure
Niraparib metabolite M1 structure
Common Name Niraparib metabolite M1
CAS Number 1476777-06-6 Molecular Weight 321.373
Density 1.3±0.1 g/cm3 Boiling Point 442.0±45.0 °C at 760 mmHg
Molecular Formula C19H19N3O2 Melting Point N/A
MSDS N/A Flash Point 221.1±28.7 °C

 Use of Niraparib metabolite M1


Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

 Names

Name Niraparib metabolite M1
Synonym More Synonyms

 Niraparib metabolite M1 Biological Activity

Description Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
Related Catalog
In Vitro Niraparib metabolite M1 has the validation in plasma and urine for the support of clinical studies such as the mass balance study and the absolute bioavailability study[1].
References

[1]. van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 442.0±45.0 °C at 760 mmHg
Molecular Formula C19H19N3O2
Molecular Weight 321.373
Flash Point 221.1±28.7 °C
Exact Mass 321.147736
LogP 4.01
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.693
Storage condition 2-8℃

 Synonyms

2-{4-[(3S)-3-Piperidinyl]phenyl}-2H-indazole-7-carboxylic acid
2H-Indazole-7-carboxylic acid, 2-[4-[(3S)-3-piperidinyl]phenyl]-
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