1476777-06-6

1476777-06-6 structure
1476777-06-6 structure
  • Name: Niraparib metabolite M1
  • Chemical Name: Niraparib metabolite M1
  • CAS Number: 1476777-06-6
  • Molecular Formula: C19H19N3O2
  • Molecular Weight: 321.373
  • Catalog: Research Areas Others
  • Create Date: 2018-05-27 23:57:27
  • Modify Date: 2024-01-06 17:17:05
  • Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

Name Niraparib metabolite M1
Synonyms 2-{4-[(3S)-3-Piperidinyl]phenyl}-2H-indazole-7-carboxylic acid
2H-Indazole-7-carboxylic acid, 2-[4-[(3S)-3-piperidinyl]phenyl]-
Description Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
Related Catalog
In Vitro Niraparib metabolite M1 has the validation in plasma and urine for the support of clinical studies such as the mass balance study and the absolute bioavailability study[1].
References

[1]. van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21.

Density 1.3±0.1 g/cm3
Boiling Point 442.0±45.0 °C at 760 mmHg
Molecular Formula C19H19N3O2
Molecular Weight 321.373
Flash Point 221.1±28.7 °C
Exact Mass 321.147736
LogP 4.01
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.693
Storage condition 2-8℃