Cefcapene pivoxil hydrochloride hydrate

Modify Date: 2024-01-02 11:28:27

Cefcapene pivoxil hydrochloride hydrate structure	Common Name	Cefcapene pivoxil hydrochloride hydrate
	CAS Number	147816-24-8	Molecular Weight	622.111
	Density	1.47 g/cm3	Boiling Point	888.4ºC at 760 mmHg
	Molecular Formula	C₂₃H₃₂ClN₅O₉S₂	Melting Point	158-164ºC
	MSDS	N/A	Flash Point	491.1ºC

Use of Cefcapene pivoxil hydrochloride hydrate

Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity[1]. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases[2].

Name	Cefcapene Pivoxil Hydrochloride Monohydrate
Synonym	More Synonyms

Description	Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity[1]. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: bacterial[1]
In Vivo	Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3]. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3] Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.
References	[1]. Murakami M, et al. Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.Dermatology. 2015;231(4):304-11. [2]. Kawada A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride.Contact Dermatitis. 2001 Mar;44(3):197. [3]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15. [4]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.

Density	1.47 g/cm3
Boiling Point	888.4ºC at 760 mmHg
Melting Point	158-164ºC
Molecular Formula	C₂₃H₃₂ClN₅O₉S₂
Molecular Weight	622.111
Flash Point	491.1ºC
Exact Mass	621.132996
PSA	256.01000
LogP	3.70600
Vapour Pressure	3.51E-32mmHg at 25°C
Storage condition	0-10°C

RTECS	XI0325000
HS Code	2941905990

HS Code	2941905990

CEFCAPENE PIVOXIL HYDROCHLORIDE HYDRATE

[(2,2-Dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-pentenoyl]amino}-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride hydrate

Flomox

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-penten-1-yl]amino]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-, hydrochloride, hydrate (1:1:1)

Cefcapene pivoxil hydrochloride

Cefcapene pivoxil hydrochloride monohydrate