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147816-24-8

147816-24-8 structure
147816-24-8 structure
  • Name: Cefcapene pivoxil hydrochloride hydrate
  • Chemical Name: Cefcapene Pivoxil Hydrochloride Monohydrate
  • CAS Number: 147816-24-8
  • Molecular Formula: C23H32ClN5O9S2
  • Molecular Weight: 622.111
  • Catalog: API Antibiotics Cephalosporin
  • Create Date: 2018-06-01 08:00:00
  • Modify Date: 2024-01-02 11:28:27
  • Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity[1]. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases[2].
Name Cefcapene Pivoxil Hydrochloride Monohydrate
Synonyms CEFCAPENE PIVOXIL HYDROCHLORIDE HYDRATE
[(2,2-Dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-pentenoyl]amino}-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride hydrate
Flomox
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-penten-1-yl]amino]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-, hydrochloride, hydrate (1:1:1)
Cefcapene pivoxil hydrochloride
Cefcapene pivoxil hydrochloride monohydrate
Description Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity[1]. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases[2].
Related Catalog
Target

IC50: bacterial[1]

In Vivo Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3]. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3] Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.
References

[1]. Murakami M, et al. Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.Dermatology. 2015;231(4):304-11.

[2]. Kawada A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride.Contact Dermatitis. 2001 Mar;44(3):197.

[3]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.

[4]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.
Density 1.47 g/cm3
Boiling Point 888.4ºC at 760 mmHg
Melting Point 158-164ºC
Molecular Formula C23H32ClN5O9S2
Molecular Weight 622.111
Flash Point 491.1ºC
Exact Mass 621.132996
PSA 256.01000
LogP 3.70600
Vapour Pressure 3.51E-32mmHg at 25°C
Storage condition 0-10°C
RTECS XI0325000
HS Code 2941905990
HS Code 2941905990

Chemsrc provides CAS#:147816-24-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 147816-24-8 | Chemsrc address: https://www.chemsrc.com/en/baike/1034060.html

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